Coming from the South (M6)
Leave the M6 at Junction 36 onto A590 (becomes A591) all the way into Windermere
Coming from the East (Leeds)
Take the M62 to the M6, then as above. Or for a scenic alternative: leave Leeds and take the A660 to Otley. Then join the A65 through Ilkley and Skipton, onto Kirkby Lonsdale, eventually crossing the M6 at Junction 36. Then as above.